A graph-based approach for proteoform identification and quantification using top-down homogeneous multiplexed tandem mass spectra
Abstract Background Top-down homogeneous multiplexed tandem mass (HomMTM) spectra are generated from modified proteoforms of the same protein with different post-translational modification patterns.They are frequently observed in the analysis of ultramodified proteins, some proteoforms of which have similar molecular weights and cannot be well sepa