A GRAPH-BASED APPROACH FOR PROTEOFORM IDENTIFICATION AND QUANTIFICATION USING TOP-DOWN HOMOGENEOUS MULTIPLEXED TANDEM MASS SPECTRA

A graph-based approach for proteoform identification and quantification using top-down homogeneous multiplexed tandem mass spectra

Abstract Background Top-down homogeneous multiplexed tandem mass (HomMTM) spectra are generated from modified proteoforms of the same protein with different post-translational modification patterns.They are frequently observed in the analysis of ultramodified proteins, some proteoforms of which have similar molecular weights and cannot be well sepa

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THE CONCEPTION OF READING THAT PERMEATES THE WORK OF THE TEACHER

This article begins from the premise that reading is not only identify words in texts; more than that, is acknowledging that these words have determined sense within the context in which they find themselves.Based on this assumption, the objective of this paper is to discuss the different conceptions of reading curtail teaching and to relate them t

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Ear replanatation: a case report and literature review

Background: Total ear amputation is a rare accident.The most common causes are traffic accidents (33 %), followed by fights (28 %).In 1980, Pennington et al.reported the first successful microsurgical ear replantation in a 29-year old man.Methods: An English literature review of trauma cases of total ear amputation showed only 13 successful replant

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